DNTTIP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9H147 |
Other Accession | NP_443183.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37013 Da |
Antigen Region | 145-174 aa |
Gene ID | 116092 |
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Other Names | Deoxynucleotidyltransferase terminal-interacting protein 1, Terminal deoxynucleotidyltransferase-interacting factor 1, TdIF1, TdT-interacting factor 1, DNTTIP1, C20orf167, TDIF1 |
Target/Specificity | This DNTTIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human DNTTIP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DNTTIP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DNTTIP1 |
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Synonyms | C20orf167, TDIF1 |
Function | Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA. |
Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).
References
Kubota, T., et al. Genes Cells 12(8):941-959(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Tomarev, S.I., et al. Invest. Ophthalmol. Vis. Sci. 44(6):2588-2596(2003)
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