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XPNPEP3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NQH7 |
| Other Accession | NP_071381.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57034 Da |
| Antigen Region | 440-469 aa |
| Gene ID | 63929 |
|---|---|
| Other Names | Probable Xaa-Pro aminopeptidase 3, X-Pro aminopeptidase 3, Aminopeptidase P3, APP3, XPNPEP3 |
| Target/Specificity | This XPNPEP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-469 amino acids from the C-terminal region of human XPNPEP3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | XPNPEP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | XPNPEP3 |
|---|---|
| Function | Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889). |
| Cellular Location | [Isoform 1]: Mitochondrion. Cytoplasm. Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation |
| Tissue Location | Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant. |
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Provided below are standard protocols that you may find useful for product applications.
Background
XPNPEP3 belongs to a family of X-pro-aminopeptidases (EC 3.4.11.9) that utilize a metal cofactor and remove the N-terminal amino acid from peptides with a proline residue in the penultimate position (summary by Ersahin et al., 2005 [PubMed 15708373]).
References
O'Toole, J.F., et al. J. Clin. Invest. 120(3):791-802(2010)
Ersahin, C., et al. Arch. Biochem. Biophys. 435(2):303-310(2005)
Bouwmeester, T., et al. Nat. Cell Biol. 6(2):97-105(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Dunham, I., et al. Nature 402(6761):489-495(1999)
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