|Application ||WB, E|
|Other Accession||NP_783856.1, NP_005627.1|
|Calculated MW||21858 Da|
|Antigen Region||63-91 aa|
|Other Names||Protein SSX4, Cancer/testis antigen 54, CT54, SSX4, SSX4A|
|Target/Specificity||This SSX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the Central region of human SSX4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SSX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could act as a modulator of transcription.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.
Ayyoub, M., et al. J. Immunol. 174(8):5092-5099(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Gure, A.O., et al. Int. J. Cancer 101(5):448-453(2002)
Brodin, B., et al. Gene 268 (1-2), 173-182 (2001) :
Chen, C.H., et al. Cancer Lett. 164(2):189-195(2001)
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