|Application ||WB, IHC-P, E|
|Calculated MW||14232 Da|
|Antigen Region||62-91 aa|
|Other Names||Glycoprotein hormone beta-5, Thyrostimulin subunit beta, GPHB5, GPB5, ZLUT1|
|Target/Specificity||This GPHB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the C-terminal region of human GPHB5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPHB5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the thyroid. Binds and activates THSR, leading to increased cAMP production.|
|Tissue Location||Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs|
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Provided below are standard protocols that you may find useful for product applications.
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).
Suzuki, C., et al. Endocrinology 150(5):2237-2243(2009) Okajima, Y., et al. Regul. Pept. 148 (1-3), 62-67 (2008) : Okada, S.L., et al. Mol. Endocrinol. 20(2):414-425(2006) Sudo, S., et al. Endocrinology 146(8):3596-3604(2005) Heilig, R., et al. Nature 421(6923):601-607(2003)
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