GPHB5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q86YW7 |
Other Accession | NP_660154.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 14232 Da |
Antigen Region | 62-91 aa |
Gene ID | 122876 |
---|---|
Other Names | Glycoprotein hormone beta-5, Thyrostimulin subunit beta, GPHB5, GPB5, ZLUT1 |
Target/Specificity | This GPHB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the C-terminal region of human GPHB5. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GPHB5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GPHB5 |
---|---|
Synonyms | GPB5, ZLUT1 |
Function | Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism. |
Cellular Location | Secreted. |
Tissue Location | Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).
References
Suzuki, C., et al. Endocrinology 150(5):2237-2243(2009) Okajima, Y., et al. Regul. Pept. 148 (1-3), 62-67 (2008) : Okada, S.L., et al. Mol. Endocrinol. 20(2):414-425(2006) Sudo, S., et al. Endocrinology 146(8):3596-3604(2005) Heilig, R., et al. Nature 421(6923):601-607(2003)
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