|Application ||WB, IHC-P, E|
|Other Accession||Q5M862, NP_079097.1|
|Calculated MW||26561 Da|
|Antigen Region||197-225 aa|
|Other Names||Coiled-coil domain-containing protein 134, CCDC134|
|Target/Specificity||This CCDC134 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the C-terminal region of human CCDC134.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCDC134 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).|
|Cellular Location||Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation (PubMed:22644376)|
|Tissue Location||Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808). Also detected in placenta (PubMed:18087676). Highest expression in testis relative to other tissues (PubMed:18087676). Detected in T cells and dendritic cells; highly expressed in activated CD8(+) T cells, and also expressed at lower levels in CD4(+) T cells (PubMed:25125657).|
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Provided below are standard protocols that you may find useful for product applications.
The specific function of this protein remains unknown.
Huang, J., et al. Cell. Mol. Life Sci. 65(2):338-349(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Dunham, I., et al. Nature 402(6761):489-495(1999)
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