|Application ||WB, IHC-P, E|
|Calculated MW||89091 Da|
|Antigen Region||411-440 aa|
|Other Names||Cadherin-22, Pituitary and brain cadherin, PB-cadherin, CDH22, C20orf25|
|Target/Specificity||This CDH22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 411-440 amino acids from the Central region of human CDH22.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDH22 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs.
Lewis, J.P., et al. Genomics (2010) In press :
Liu, Y., et al. Cancer Biol. Ther. 8(14):1352-1359(2009)
Zhou, J., et al. Tumour Biol. 30(3):130-140(2009)
Bento, J.L., et al. Genomics 92(4):226-234(2008)
Wu, J., et al. J. Endocrinol. 176(3):381-391(2003)
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