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CASP10 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CASP10 Antibody (Center) AP1326c
    Western blot analysis of CASP10 antibody (Center) (Cat.#AP1326c) in HepG2 cell line lysates (35ug/lane). CASP10 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92851
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58951 Da
Antigen Region 164-192 aa
Additional Information
Gene ID 843
Other Names Caspase-10, CASP-10, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, Caspase-10 subunit p23/17, Caspase-10 subunit p12, CASP10, MCH4
Target/Specificity This CASP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-192 amino acids from the Central region of human CASP10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCASP10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP10
Synonyms MCH4
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.
Tissue Location Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon
Research Areas
Citations (0)

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CASP10 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in the protein are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.


Lan,Q., Morton,L.M. Blood 114 (2), 264-267 (2009)
Kim,Y.R., Kim,K.M. Hum. Pathol. 40 (6), 868-871 (2009)
Lisa-Santamaria,P. Biochim. Biophys. Acta 1793 (3), 561-571 (2009)

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$ 295.00
$ 99.00
Cat# AP1326c
(40 western blots)
Availability: In Stock
Bulk Size
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