|Application ||WB, E|
|Other Accession||Q60HH0, NP_001035897.1, NP_000077.1|
|Calculated MW||47623 Da|
|Antigen Region||235-263 aa|
|Other Names||Battenin, Batten disease protein, Protein CLN3, CLN3, BTS|
|Target/Specificity||This CLN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CLN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLN3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.|
|Cellular Location||Lysosome membrane; Multi- pass membrane protein. Late endosome. Lysosome|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene.
Adams, H.R., et al. Dev Med Child Neurol 52(7):637-643(2010)
Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)
Sarpong, A., et al. Clin. Genet. 76(1):38-45(2009)
Codlin, S., et al. J. Cell. Sci. 122 (PT 8), 1163-1173 (2009) :
Tuxworth, R.I., et al. Hum. Mol. Genet. 18(4):667-678(2009)
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