|Application ||WB, E|
|Other Accession||Q5U2Y0, Q91VM3, Q7ZUX3, NP_009006.2, NP_001025067.1|
|Predicted||Zebrafish, Mouse, Rat|
|Calculated MW||39868 Da|
|Antigen Region||17-46 aa|
|Other Names||WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat-containing protein 45, WDR45, WDRX1, WDRXI4, WIPI4|
|Target/Specificity||This WDR45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human WDR45.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WDR45 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||WDRX1, WDRXI4, WIPI4|
|Function||Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.|
|Tissue Location||Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.
Proikas-Cezanne, T., et al. Oncogene 23(58):9314-9325(2004)
Jeffries, T.R., et al. Mol. Biol. Cell 15(6):2652-2663(2004)
Clark, A.G., et al. Science 302(5652):1960-1963(2003)
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