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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > MOSPD2 Antibody (N-term )
MOSPD2 Antibody (N-term )
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8NHP6 |
| Other Accession | NP_001170946.1, NP_689794.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59746 Da |
| Antigen Region | 11-40 aa |
| Gene ID | 158747 |
|---|---|
| Other Names | Motile sperm domain-containing protein 2, MOSPD2 |
| Target/Specificity | This MOSPD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human MOSPD2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MOSPD2 Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MOSPD2 (HGNC:28381) |
|---|---|
| Function | Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:35389430, PubMed:33124732). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localization to contact sites involving the endoplasmic reticulum and several organelles is regulated by interaction with proteins containing FFAT motif (PubMed:29858488) Dynamically distributes between specific subdomains of the endoplasmic reticulum (ER): ER membranes in contact with lipid droplets (LDs) and the remainder of the ER (PubMed:35389430) |
| Tissue Location | Highly expressed in CD14(+) monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of this protein remains unknown.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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$ 182.50
$ 70.00
Cat# AP13323a
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