|Application ||WB, IHC-P, E|
|Calculated MW||22285 Da|
|Antigen Region||9-38 aa|
|Other Names||Apolipoprotein O, Protein FAM121B, APOO, FAM121B|
|Target/Specificity||This APOO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human APOO.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APOO Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.|
|Cellular Location||Membrane; Single-pass membrane protein. Secreted|
|Tissue Location||Expressed in all tissues examined. Up- regulated in diabetic heart.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Lamant, M., et al. J. Biol. Chem. 281(47):36289-36302(2006)
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