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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   APOO Antibody (N-term )   

APOO Antibody (N-term )

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - APOO Antibody (N-term ) AP13324a
    APOO Antibody (N-term ) (Cat. #AP13324a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the APOO antibody detected the APOO protein (arrow).
  • IHC-P - APOO Antibody (N-term ) AP13324a
    APOO Antibody (N-term) (Cat. #AP13324a)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of APOO Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BUR5
Other Accession NP_077027.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22285 Da
Antigen Region 9-38 aa
Additional Information
Gene ID 79135
Other Names Apolipoprotein O, Protein FAM121B, APOO, FAM121B
Target/Specificity This APOO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human APOO.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPOO Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOO
Function Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892).
Cellular Location Mitochondrion inner membrane; Single-pass membrane protein. Secreted. Mitochondrion. Golgi apparatus membrane. Endoplasmic reticulum membrane. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form
Tissue Location Expressed in all tissues examined. Up- regulated in diabetic heart.
Research Areas
Citations (0)

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Background

This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Lamant, M., et al. J. Biol. Chem. 281(47):36289-36302(2006)

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$ 295.00
$ 99.00
Cat# AP13324a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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