|Application ||WB, IHC-P, E|
|Calculated MW||19856 Da|
|Antigen Region||71-99 aa|
|Other Names||Mimitin, mitochondrial, B172-like, B172L, Myc-induced mitochondrial protein, MMTN, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2, NDUFA12-like protein, NDUFAF2, NDUFA12L|
|Target/Specificity||This NDUFAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the Central region of human NDUFAF2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NDUFAF2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a molecular chaperone for mitochondrial complex I assembly.|
|Tissue Location||Highly expressed in ESCC cells. Also expressed in heart, skeletal muscle, liver, and in fibroblasts|
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Provided below are standard protocols that you may find useful for product applications.
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lesch, K.P., et al. Mol. Psychiatry (2010) In press :
Herzer, M., et al. Neuropediatrics 41(1):30-34(2010)
Hoefs, S.J., et al. Hum. Mutat. 30 (7), E728-E736 (2009) :
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
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