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PRRG1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14668 |
| Other Accession | A7Z070, NP_001166960.1, NP_000941.1, NP_001135867.1, NP_001166957.1, NP_001166961.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 24947 Da |
| Antigen Region | 30-59 aa |
| Gene ID | 5638 |
|---|---|
| Other Names | Transmembrane gamma-carboxyglutamic acid protein 1, Proline-rich gamma-carboxyglutamic acid protein 1, Proline-rich Gla protein 1, PRRG1, PRGP1, TMG1 |
| Target/Specificity | This PRRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human PRRG1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRRG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRRG1 |
|---|---|
| Synonyms | PRGP1, TMG1 |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in the spinal cord. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Kulman, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 94(17):9058-9062(1997)
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