|Application ||WB, E|
|Calculated MW||27614 Da|
|Antigen Region||39-68 aa|
|Other Names||Phosducin-like protein 3, HTPHLP, PhPL3, Viral IAP-associated factor 1, VIAF-1, PDCL3, PhLP2A, VIAF1|
|Target/Specificity||This PDCL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human PDCL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDCL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination.|
|Tissue Location||Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq].
Stirling, P.C., et al. Mol. Biol. Cell 18(6):2336-2345(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wilkinson, J.C., et al. J. Biol. Chem. 279(49):51091-51099(2004)
Lopez, P., et al. J. Biol. Chem. 278(3):1751-1757(2003)
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