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APCDD1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - APCDD1 Antibody (N-term) AP13356a
    APCDD1 Antibody (N-term) (Cat. #AP13356a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the APCDD1 antibody detected the APCDD1 protein (arrow).
  • IHC-P - APCDD1 Antibody (N-term) AP13356a
    APCDD1 Antibody (N-term) (Cat. #AP13356a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of APCDD1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8J025
Other Accession Q66KI8, NP_694545.1
Reactivity Human
Predicted Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 58797 Da
Antigen Region 69-98 aa
Additional Information
Gene ID 147495
Other Names Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein, APCDD1 (HGNC:15718)
Target/Specificity This APCDD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the N-terminal region of human APCDD1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPCDD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APCDD1 (HGNC:15718)
Function Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level).
Research Areas
Citations (0)

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This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.


Shimomura, Y., et al. Nature 464(7291):1043-1047(2010)
Takahashi, M., et al. Cancer Res. 62(20):5651-5656(2002)

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Cat# AP13356a
(40 western blots)
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