|Application ||WB, E|
|Other Accession||NP_001156793.1, NP_001156794.1, NP_296375.1, NP_001156795.1|
|Calculated MW||67567 Da|
|Antigen Region||59-88 aa|
|Other Names||Coiled-coil domain-containing protein 120, CCDC120|
|Target/Specificity||This CCDC120 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the N-terminal region of human CCDC120.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCDC120 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.|
|Cellular Location||Cytoplasm. Cell projection. Cell projection, growth cone. Endosome. Note=In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas. Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a coiled-coil domain. Four alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Tarpey, P.S., et al. Nat. Genet. 41(5):535-543(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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