DHFRL1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q86XF0 |
Other Accession | NP_789785.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 21620 Da |
Antigen Region | 45-74 aa |
Gene ID | 200895 |
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Other Names | Dihydrofolate reductase, mitochondrial, Dihydrofolate reductase-like protein 1, DHFRL1, DHFRP4 |
Target/Specificity | This DHFRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the Central region of human DHFRL1. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DHFRL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DHFR2 (HGNC:27309) |
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Synonyms | DHFRL1, DHFRP4 |
Function | Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR. |
Cellular Location | Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane |
Tissue Location | Expressed in numerous cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DHFRL1 may play a role in folate metabolism (Potential).
References
Semmler, A., et al. J. Neurosurg. 108(5):999-1004(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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