|Application ||WB, IHC-P, E|
|Calculated MW||21620 Da|
|Antigen Region||45-74 aa|
|Other Names||Dihydrofolate reductase, mitochondrial, Dihydrofolate reductase-like protein 1, DHFRL1, DHFRP4|
|Target/Specificity||This DHFRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the Central region of human DHFRL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DHFRL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Binds its own mRNA and that of DHFR.|
|Cellular Location||Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane|
|Tissue Location||Expressed in numerous cell lines.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DHFRL1 may play a role in folate metabolism (Potential).
Semmler, A., et al. J. Neurosurg. 108(5):999-1004(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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