|Application ||WB, IHC-P, E|
|Other Accession||NP_072092.2, NP_922940.1, NP_922939.1|
|Calculated MW||27627 Da|
|Antigen Region||70-98 aa|
|Other Names||C-type lectin domain family 7 member A, Beta-glucan receptor, C-type lectin superfamily member 12, Dendritic cell-associated C-type lectin 1, DC-associated C-type lectin 1, Dectin-1, CLEC7A, BGR, CLECSF12, DECTIN1|
|Target/Specificity||This CLEC7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human CLEC7A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC7A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BGR, CLECSF12, DECTIN1|
|Function||Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).|
|Cellular Location||Cell membrane; Single- pass type II membrane protein Isoform 6: Cytoplasm.|
|Tissue Location||Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
de Koning, H.D., et al. J. Invest. Dermatol. 130(11):2611-2620(2010)
Plantinga, T.S., et al. J. Acquir. Immune Defic. Syndr. 55(1):87-94(2010)
Cunha, C., et al. Blood (2010) In press :
van der Velden, W.J., et al. Clin. Immunol. 136(2):302-306(2010)
Kankkunen, P., et al. J. Immunol. 184(11):6335-6342(2010)
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