|Application ||WB, IHC-P, E|
|Other Accession||Q920J4, Q8CDN6|
|Calculated MW||32251 Da|
|Antigen Region||256-289 aa|
|Other Names||Thioredoxin-like protein 1, 32 kDa thioredoxin-related protein, TXNL1, TRP32, TXL, TXNL|
|Target/Specificity||This TXNL1 (TRP32/TrxL) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-289 amino acids from the C-terminal region of human TXNL1 (TRP32/TrxL).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TXNL1 (TRP32/TrxL) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||TRP32, TXL, TXNL|
|Function||Active thioredoxin with a redox potential of about -250 mV.|
|Cellular Location||Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated|
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Provided below are standard protocols that you may find useful for product applications.
Thioredoxins are a group of small redox active proteins possessing a conserved active site sequence. TrxL (Thioredoxin like protein 1) has 2 distinct domains: an N terminal domain, which is 43% identical to human TXN, and a C terminal domain, which shows no homology to other proteins in the sequence databases. The active site sequence, located within the N terminal domain, is that of a thioredoxin like protein; compared to the active site sequence of TXN, it has a single amino acid substitution. Unlike other thioredoxin like proteins, TrxL does not serve as a substrate for thioredoxin reductase in an insulin assay.
Miranda-Vizuete, A., et al., Biochem. Biophys. Res. Commun. 243: 284-288 (1998).
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