FRMD7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q6ZUT3 |
Other Accession | NP_919253.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 81614 Da |
Antigen Region | 115-144 aa |
Gene ID | 90167 |
---|---|
Other Names | FERM domain-containing protein 7, FRMD7 |
Target/Specificity | This FRMD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-144 amino acids from the N-terminal region of human FRMD7. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FRMD7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FRMD7 |
---|---|
Function | Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. |
Cellular Location | Cell projection, neuron projection {ECO:0000250|UniProtKB:A2AD83}. Cell projection, growth cone {ECO:0000250|UniProtKB:A2AD83}. Note=In undifferentiated neurons, located in the actin-rich regions of the cell body. In differentiated neurons, located in the actin-rich regions of the cell body and primary neurite processes but is almost absent from secondary extensions arising from the primary neurite. Also found at the actin-rich distal end of growth cones (By similarity). {ECO:0000250|UniProtKB:A2AD83} |
Tissue Location | Expressed in liver, kidney, pancreas and at low levels in brain and heart. Expressed in embryonic brain and developing neural retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mutations in this gene are associated with X-linked congenital nystagmus.
References
Fingert, J.H., et al. Ophthalmic Genet. 31(2):77-80(2010)
Betts-Henderson, J., et al. Hum. Mol. Genet. 19(2):342-351(2010)
He, X., et al. Genet. Test. 12(4):607-613(2008)
Thomas, S., et al. Brain 131 (PT 5), 1259-1267 (2008) :
Li, N., et al. Mol. Vis. 14, 733-738 (2008) :
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