UPRT Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q96BW1 |
Other Accession | Q95KB0, Q5ZIJ8, Q32LA4, NP_659489.1 |
Reactivity | Mouse |
Predicted | Bovine, Chicken, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33786 Da |
Antigen Region | 204-233 aa |
Gene ID | 139596 |
---|---|
Other Names | Uracil phosphoribosyltransferase homolog, UPRT |
Target/Specificity | This UPRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-233 amino acids from the C-terminal region of human UPRT. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | UPRT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | UPRT |
---|---|
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer.
References
Zhao, F.J., et al. Prostate Cancer Prostatic Dis. 12(2):166-171(2009)
Li, J., et al. J. Hum. Genet. 52(5):415-422(2007)
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