|Application ||WB, IHC-P, E|
|Calculated MW||36018 Da|
|Antigen Region||285-316 aa|
|Other Names||BCL2/adenovirus E1B 19 kDa protein-interacting protein 2, BNIP2, NIP2|
|Target/Specificity||This BNIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-316 amino acids from the C-terminal region of human BNIP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BNIP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector.
Scott, G.B., et al. Biochem. J. 431(3):423-431(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Valencia, C.A., et al. Biochem. Biophys. Res. Commun. 364(3):495-501(2007)
Zhou, Y.T., et al. Exp. Cell Res. 303(2):263-274(2005)
Shang, X., et al. J. Biol. Chem. 278(46):45903-45914(2003)
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