|Application ||WB, E|
|Other Accession||P97615, P97493, Q95108|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||18383 Da|
|Antigen Region||136-166 aa|
|Other Names||Thioredoxin, mitochondrial, MTRX, Mt-Trx, Thioredoxin-2, TXN2, TRX2|
|Target/Specificity||This Thioredoxin 2 (Trx2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-166 amino acids from the C-terminal region of human Thioredoxin 2 (Trx2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Thioredoxin 2 (Trx2) Antibody (c-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.|
|Tissue Location||Widely expressed in adult (at protein level) and fetal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
TRX2 is a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.
J. Biol. Chem. 277 (36), 33249-33257 (2002)
J. Biol. Chem. 277 (36), 33242-33248 (2002)
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