|Application ||WB, IHC-P, E|
|Other Accession||NP_004248.2, NP_001136093.1|
|Calculated MW||97158 Da|
|Antigen Region||499-528 aa|
|Other Names||Transforming growth factor-beta receptor-associated protein 1, TGF-beta receptor-associated protein 1, TRAP-1, TRAP1, TGFBRAP1|
|Target/Specificity||This TGFBRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-528 amino acids from the C-terminal region of human TGFBRAP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TGFBRAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.|
|Cellular Location||Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling|
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Provided below are standard protocols that you may find useful for product applications.
TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)
Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)
Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)
Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999)
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