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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TGFBRAP1 Antibody (C-term)   

TGFBRAP1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TGFBRAP1 Antibody (C-term) AP13395b
    TGFBRAP1 Antibody (C-term) (Cat. #AP13395b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TGFBRAP1 antibody detected the TGFBRAP1 protein (arrow).
  • IHC-P - TGFBRAP1 Antibody (C-term) AP13395b
    TGFBRAP1 Antibody (C-term) (Cat. #AP13395b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TGFBRAP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8WUH2
Other Accession NP_004248.2, NP_001136093.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 97158 Da
Antigen Region 499-528 aa
Additional Information
Gene ID 9392
Other Names Transforming growth factor-beta receptor-associated protein 1, TGF-beta receptor-associated protein 1, TRAP-1, TRAP1, TGFBRAP1
Target/Specificity This TGFBRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-528 amino acids from the C-terminal region of human TGFBRAP1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGFBRAP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGFBRAP1
Function Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
Cellular Location Cytoplasm. Early endosome. Note=Colocalizes with TGF-beta receptors in the absence of signaling
Research Areas
Citations (0)

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Background

TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)
Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)
Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)
Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999)

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$ 295.00
$ 99.00
Cat# AP13395b
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Quantity:
(40 western blots)
Availability: In Stock
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