|Application ||WB, E|
|Calculated MW||34787 Da|
|Antigen Region||286-314 aa|
|Other Names||Dual oxidase maturation factor 2, Dual oxidase activator 2, DUOXA2|
|Target/Specificity||This DUOXA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-314 amino acids from the C-terminal region of human DUOXA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUOXA2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Specifically expressed in thyroid. Also detected in salivary glands.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.
Luxen, S., et al. J. Cell. Sci. 122 (PT 8), 1238-1247 (2009) :
Zamproni, I., et al. J. Clin. Endocrinol. Metab. 93(2):605-610(2008)
Eriksson, A., et al. BMC Gastroenterol 8, 34 (2008) :
Grasberger, H., et al. Mol. Endocrinol. 21(6):1408-1421(2007)
Grasberger, H., et al. J. Biol. Chem. 281(27):18269-18272(2006)
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