|Application ||WB, E|
|Calculated MW||37654 Da|
|Antigen Region||226-253 aa|
|Other Names||T-cell surface glycoprotein CD1c, CD1c, CD1C|
|Target/Specificity||This CD1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-253 amino acids from the C-terminal region of human CD1C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD1C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Lysosome. Note=Subject to intracellular trafficking between the cell membrane and endosomes|
|Tissue Location||Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.
Van Brussel, I., et al. J. Immunol. Methods 362 (1-2), 168-175 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Garzon, D., et al. Mol. Immunol. 47 (2-3), 253-260 (2009) :
Van Rhijn, I., et al. J. Exp. Med. 206(6):1409-1422(2009)
Kaser, A., et al. Eur. J. Immunol. 38(8):2351-2359(2008)
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