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BLNK Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13433a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13433a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
BLNK Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q8WV28 |
| Other Accession | Q4KM52, Q9QUN3, NP_037446.1, NP_001107566.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 50466 Da |
BLNK Antibody (N-term) - Additional info | |
| Gene ID 29760 | |
| Other Names BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa | |
| Target/Specificity This BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-82 amino acids from the N-terminal region of human BLNK. | |
| Dilution WB~~1:50~100WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions BLNK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
BLNK Antibody (N-term) - Protein Information | |
| Name BLNK | |
| Synonyms BASH, SLP65 | |
| Function Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis | |
| Cellular Location Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction | |
| Tissue Location Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon | |
BLNK Antibody (N-term) - Related products
AP13433a: BLNK Antibody (N-term)
AP6502c: BLNK Antibody (Center)
DC04766: Human BLNK cDNA Clone
LY10908a: BLNK Over-expression Lysate
BLNK Antibody (N-term) - Application data
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Western blot analysis of BLNK (arrow) using rabbit polyclonal BLNK Antibody (N-term) (Cat. #AP13433a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the BLNK gene.
BLNK Antibody (N-term) - Research Areas
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BACKGROUND
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Davila, S., et al. Genes Immun. 11(3):232-238(2010) Oellerich, T., et al. Mol. Cell Proteomics 8(7):1738-1750(2009) Imamura, Y., et al. J. Biol. Chem. 284(15):9804-9813(2009) Li, H., et al. PLoS ONE 4 (7), E6410 (2009) :
