|Application ||WB, IHC-P, E|
|Calculated MW||67942 Da|
|Antigen Region||445-474 aa|
|Other Names||Endogenous retrovirus group 3 member 1 Env polyprotein, ERV-3 envelope protein, ERV3 envelope protein, ERV3-1 envelope protein, Envelope polyprotein, HERV-R envelope protein, ERV-R envelope protein, HERV-R_7q212 provirus ancestral Env polyprotein, Surface protein, SU, Transmembrane protein, TM, ERV3-1, ERV3|
|Target/Specificity||This ERV3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human ERV3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ERV3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro.|
|Tissue Location||Expressed at higher level in adrenal, sebaceous glands and placenta. Expressed at lower level in bone marrow, brain, breast, colon, heart, kidney, liver, lung, ovary, PBL, prostate, skin, spleen, testis, thymus, thyroid, trachea|
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Provided below are standard protocols that you may find useful for product applications.
The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma. [provided by RefSeq].
Andersson, A.C., et al. J. Virol. 79(14):9270-9284(2005)
Herve, C.A., et al. Genomics 83(5):940-943(2004)
Blaise, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(22):13013-13018(2003)
de Parseval, N., et al. J. Virol. 77(19):10414-10422(2003)
Andersson, A.C., et al. Virology 297(2):220-225(2002)
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