|Application ||WB, IHC-P, E|
|Other Accession||Q3ZBK2, NP_115709.3|
|Calculated MW||25764 Da|
|Antigen Region||181-209 aa|
|Other Names||Redox-regulatory protein FAM213A, Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, FAM213A, C10orf58, PAMM|
|Target/Specificity||This C10orf58 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human C10orf58.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C10orf58 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).|
|Cellular Location||Cytoplasm. Secreted. Note=Secreted from mature adipocytes but not from preadipocytes|
|Tissue Location||Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The specific function of the protein remains unknown.
Castellano, S., et al. EMBO Rep. 5(1):71-77(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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