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MAGED4B Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MAGED4B Antibody (Center) AP13447c
    MAGED4B Antibody (Center) (Cat. #AP13447c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MAGED4B antibody detected the MAGED4B protein (arrow).
    detail
  • IHC-P - MAGED4B Antibody (Center) AP13447c
    MAGED4B Antibody (Center) (Cat. #AP13447c)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MAGED4B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q96JG8
Other Accession A6QLI5, NP_803881.1, NP_803879.1, NP_001092270.1, NP_110428.2
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 81378 Da
Antigen Region 328-357 aa
Additional Information
Gene ID 728239;81557
Other Names Melanoma-associated antigen D4, MAGE-D4 antigen, MAGE-E1 antigen, MAGED4, KIAA1859, MAGED4A, MAGEE1
Target/Specificity This MAGED4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 328-357 amino acids from the Central region of human MAGED4B.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAGED4B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGED4
Synonyms KIAA1859, MAGED4A, MAGEE1
Function May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Tissue Location Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.
Research Areas
Citations (0)
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Background

This gene is a member of the MAGED gene family. It is expressed only in brain and ovary among normal tissues, and two transcript variants of this gene are specifically expressed in glioma cells among cancer cells. This gene and the other MAGED genes are clustered on chromosome Xp11. Multiple alternatively spliced transcript variants have been found for this gene, however, the full-length nature of some variants has not been defined.

References

Ito, S., et al. Lung Cancer 51(1):79-88(2006)
Kawano, Y., et al. Gene 277 (1-2), 129-137 (2001) :
Sasaki, M., et al. Cancer Res. 61(12):4809-4814(2001)

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$ 365.00
$ 140.00
Cat# AP13447c
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