|Application ||WB, IHC-P, E|
|Other Accession||A6QLI5, NP_803881.1, NP_803879.1, NP_001092270.1, NP_110428.2|
|Calculated MW||81378 Da|
|Antigen Region||328-357 aa|
|Other Names||Melanoma-associated antigen D4, MAGE-D4 antigen, MAGE-E1 antigen, MAGED4, KIAA1859, MAGED4A, MAGEE1|
|Target/Specificity||This MAGED4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 328-357 amino acids from the Central region of human MAGED4B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAGED4B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1859, MAGED4A, MAGEE1|
|Function||May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.|
|Tissue Location||Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the MAGED gene family. It is expressed only in brain and ovary among normal tissues, and two transcript variants of this gene are specifically expressed in glioma cells among cancer cells. This gene and the other MAGED genes are clustered on chromosome Xp11. Multiple alternatively spliced transcript variants have been found for this gene, however, the full-length nature of some variants has not been defined.
Ito, S., et al. Lung Cancer 51(1):79-88(2006)
Kawano, Y., et al. Gene 277 (1-2), 129-137 (2001) :
Sasaki, M., et al. Cancer Res. 61(12):4809-4814(2001)
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