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BRD7 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP13451a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13451a-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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BRD7 Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q9NPI1 |
| Other Accession | NP_001167455.1, NP_037395.2 |
| Reactivity | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 74139 Da |
BRD7 Antibody (N-term) - Additional info | |
| Gene ID 29117 | |
| Other Names BRD7; BP75; CELTIX1; Bromodomain-containing protein 7; 75 kDa bromodomain protein; Protein CELTIX-1 | |
| Target/Specificity This BRD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-107 amino acids from the N-terminal region of human BRD7. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions BRD7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
BRD7 Antibody (N-term) - Protein Information | |
| Name BRD7 | |
| Synonyms BP75, CELTIX1 | |
| Function Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase | |
| Cellular Location Isoform 2: Nucleus. | |
BRD7 Antibody (N-term) - Related products
BRD7 Antibody (N-term) - Application data
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BRD7 Antibody (N-term) (Cat. #AP13451a) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the BRD7 antibody detected the BRD7 protein (arrow).
BRD7 Antibody (N-term) - Research Areas
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BACKGROUND
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.
REFERENCES
Burrows, A.E., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14280-14285(2010) Drost, J., et al. Nat. Cell Biol. 12(4):380-389(2010) Kikuchi, M., et al. Biochim. Biophys. Acta 1793(12):1828-1836(2009) Kaeser, M.D., et al. J. Biol. Chem. 283(47):32254-32263(2008) Liu, H., et al. BMC Mol. Biol. 9, 111 (2008) :
