|Application ||WB, E|
|Other Accession||NP_001167455.1, NP_037395.2|
|Calculated MW||74139 Da|
|Antigen Region||77-106 aa|
|Other Names||Bromodomain-containing protein 7, 75 kDa bromodomain protein, Protein CELTIX-1, BRD7, BP75, CELTIX1|
|Target/Specificity||This BRD7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the N-terminal region of human BRD7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BRD7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.|
|Cellular Location||Isoform 2: Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.
Burrows, A.E., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14280-14285(2010)
Drost, J., et al. Nat. Cell Biol. 12(4):380-389(2010)
Kikuchi, M., et al. Biochim. Biophys. Acta 1793(12):1828-1836(2009)
Kaeser, M.D., et al. J. Biol. Chem. 283(47):32254-32263(2008)
Liu, H., et al. BMC Mol. Biol. 9, 111 (2008) :
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