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PELI3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PELI3 Antibody (N-term) AP13453A
    PELI3 Antibody (N-term) (Cat. #AP13453a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the PELI3 antibody detected the PELI3 protein (arrow).
  • FC - PELI3 Antibody (N-term) AP13453A
    PELI3 Antibody (N-term) (Cat. #AP13453a) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N2H9
Other Accession NP_001091980.1, NP_659502.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50755 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 246330
Other Names E3 ubiquitin-protein ligase pellino homolog 3, Pellino-3, 632-, PELI3
Target/Specificity This PELI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PELI3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPELI3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PELI3
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation.
Tissue Location Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung
Research Areas
Citations (0)

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Toll-like receptors (TLRs; see MIM 603030) and IL1R (IL1R1; MIM 147810) are part of the innate immune response aimed at mobilizing defense mechanisms in response in infection or injury. Pellino proteins, such as PELI3, are intermediate components in the signaling cascades initiated by TLRs and IL1R (Jensen and Whitehead, 2003 [PubMed 12874243]).


Xiao, H., et al. J. Biol. Chem. 283(21):14654-14664(2008)
Butler, M.P., et al. J. Biol. Chem. 280(30):27759-27768(2005)
Jensen, L.E., et al. J. Immunol. 171(3):1500-1506(2003)

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$ 295.00
$ 99.00
Cat# AP13453A
(40 western blots)
Availability: In Stock
Bulk Size
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