|Application ||WB, IHC-P, E|
|Other Accession||Q9QUR2, Q8CBY8, NP_057305.1|
|Calculated MW||52337 Da|
|Antigen Region||1-30 aa|
|Other Names||Dynactin subunit 4, Dyn4, Dynactin subunit p62, DCTN4|
|Target/Specificity||This DCTN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DCTN4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCTN4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels.|
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Provided below are standard protocols that you may find useful for product applications.
DCTN4 could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Ayalon, G., et al. Cell 135(7):1189-1200(2008)
Lim, C.M., et al. J. Biol. Chem. 281(20):14006-14014(2006)
Boultwood, J., et al. Genomics 66(1):26-34(2000)
Karki, S., et al. J. Biol. Chem. 275(7):4834-4839(2000)
Bingham, J.B., et al. Curr. Biol. 9(4):223-226(1999)
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