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C11orf59 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | ||||
| AP13455a | DISCONTINED INQUIRE CLICK INQUIRE Add to cart | |||
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
C11orf59 Antibody (N-term) - Product info | |
| Application | WB
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| Primary Accession | Q6IAA8 |
| Other Accession | Q9CQ22, Q3T0D8, NP_060377.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 17745 Da |
C11orf59 Antibody (N-term) - Additional info | |
| Gene ID 55004 | |
| Other Names LAMTOR1; C11orf59; PDRO; Ragulator complex protein LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; Protein associated with DRMs and endosomes; p27Kip1-releasing factor from RhoA | |
| Target/Specificity This C11orf59 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human C11orf59. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions C11orf59 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
C11orf59 Antibody (N-term) - Protein Information | |
| Name LAMTOR1 | |
| Synonyms C11orf59, PDRO | |
| Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation | |
| Cellular Location Late endosome membrane; Lipid-anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane | |
C11orf59 Antibody (N-term) - Related products
C11orf59 Antibody (N-term) - Application data
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C11orf59 Antibody (N-term) (Cat. #AP13455a) western blot analysis in UM cell line lysates (35ug/lane).This demonstrates the C11orf59 antibody detected the C11orf59 protein (arrow).
C11orf59 Antibody (N-term) - Research Areas
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BACKGROUND
C11orf59 activates RHOA. Binds to CDKN1B and prevents interaction of CDKN1B and RHOA. This leaves RHOA in a form accessible to ARHGEF2, thereby promoting ARHGEF2-mediated exchange of GDP for GTP.
REFERENCES
Sancak, Y., et al. Cell 141(2):290-303(2010) Guillaumot, P., et al. PLoS ONE 5 (6), E10977 (2010) : Hoshino, D., et al. J. Biol. Chem. 284(40):27315-27326(2009) Nada, S., et al. EMBO J. 28(5):477-489(2009) Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
