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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ULK3 Antibody (C-term)   

ULK3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ULK3 Antibody (C-term) AP13473b
    ULK3 Antibody (C-term) (Cat. #AP13473b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ULK3 antibody detected the ULK3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6PHR2
Other Accession NP_001092906.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53444 Da
Antigen Region 347-375 aa
Additional Information
Gene ID 25989
Other Names Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3, ULK3
Target/Specificity This ULK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-375 amino acids from the C-terminal region of human ULK3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsULK3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ULK3
Function Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Cellular Location Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence
Tissue Location Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord
Research Areas
Citations (0)

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Serine/threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI-dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.


Maloverjan, A., et al. J. Biol. Chem. 285(39):30079-30090(2010)
Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)
Maloverjan, A., et al. Exp. Cell Res. 316(4):627-637(2010)
Levy, D., et al. Nat. Genet. 41(6):677-687(2009)
Kim, D.H., et al. Blood 113(11):2517-2525(2009)

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$ 295.00
$ 99.00
Cat# AP13473b
(40 western blots)
Availability: In Stock
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