|Application ||WB, E|
|Calculated MW||32288 Da|
|Antigen Region||45-73 aa|
|Other Names||Serine/arginine-rich splicing factor 8, Pre-mRNA-splicing factor SRP46, Splicing factor SRp46, Splicing factor, arginine/serine-rich 2B, SRSF8, SFRS2B, SRP46|
|Target/Specificity||This SFRS2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the N-terminal region of human SFRS2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SFRS2B Antibody (N-term ) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA alternative splicing.|
|Tissue Location||Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus|
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Provided below are standard protocols that you may find useful for product applications.
The SR (serine/arginine-rich) family contains a number of phosphoproteins that function as essential and alternative splicing factors. The SR family of proteins is characterized by the presence of a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The protein encoded by this gene is a member of the SR family and functions as an essential splicing factor in vitro. This gene is thought to be an expressed PR264/SC35 retropseudogene.
Manley, J.L., et al. Genes Dev. 24(11):1073-1074(2010)
Lareau, L.F., et al. Nature 446(7138):926-929(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Li, J., et al. Mol. Cell. Biol. 23(21):7437-7447(2003)
Grottke, C., et al. Int. J. Cancer 88(4):535-546(2000)
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