|Application ||WB, IHC-P, E|
|Other Accession||P86182, Q9JIG7, Q1RMI8, NP_054727.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||70756 Da|
|Antigen Region||530-558 aa|
|Other Names||Coiled-coil domain-containing protein 22, CCDC22, CXorf37|
|Target/Specificity||This CCDC22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-558 amino acids from the C-terminal region of human CCDC22.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCDC22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF- kappa-B activity via assocation with COMMD1 and involving a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).|
|Tissue Location||Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The specific function of the protein remains unknown.
Suttner, K., et al. J. Allergy Clin. Immunol. 125(6):1395-1399(2010)
Tomsig, J.L., et al. J. Biol. Chem. 278(12):10048-10054(2003)
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