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CCDC22 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CCDC22 Antibody (C-term) AP13480b
    CCDC22 Antibody (C-term) (Cat. #AP13480b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the CCDC22 antibody detected the CCDC22 protein (arrow).
    detail
  • IHC-P - CCDC22 Antibody (C-term) AP13480b
    CCDC22 Antibody (C-term) (Cat. #AP13480b)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CCDC22 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O60826
Other Accession P86182, Q9JIG7, Q1RMI8, NP_054727.1
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 70756 Da
Antigen Region 530-558 aa
Additional Information
Gene ID 28952
Other Names Coiled-coil domain-containing protein 22, CCDC22, CXorf37
Target/Specificity This CCDC22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-558 amino acids from the C-terminal region of human CCDC22.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCDC22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCDC22
Synonyms CXorf37
Function Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).
Cellular Location Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Tissue Location Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle.
Research Areas
Citations (0)
citation

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Background

The specific function of the protein remains unknown.

References

Suttner, K., et al. J. Allergy Clin. Immunol. 125(6):1395-1399(2010)
Tomsig, J.L., et al. J. Biol. Chem. 278(12):10048-10054(2003)

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$ 365.00
$ 140.00
Cat# AP13480b
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