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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CCDC22 Antibody (C-term)   

CCDC22 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCDC22 Antibody (C-term) AP13480b
    CCDC22 Antibody (C-term) (Cat. #AP13480b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the CCDC22 antibody detected the CCDC22 protein (arrow).
  • IHC-P - CCDC22 Antibody (C-term) AP13480b
    CCDC22 Antibody (C-term) (Cat. #AP13480b)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CCDC22 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60826
Other Accession P86182, Q9JIG7, Q1RMI8, NP_054727.1
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70756 Da
Antigen Region 530-558 aa
Additional Information
Gene ID 28952
Other Names Coiled-coil domain-containing protein 22, CCDC22, CXorf37
Target/Specificity This CCDC22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 530-558 amino acids from the C-terminal region of human CCDC22.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCDC22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCDC22
Synonyms CXorf37
Function Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF- kappa-B activity via assocation with COMMD1 and involving a CUL2- dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).
Cellular Location Endosome.
Tissue Location Widely expressed in adult tissues and in fetal liver and brain, with highest levels in prostate and lowest in skeletal muscle.
Research Areas
Citations (0)

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The specific function of the protein remains unknown.


Suttner, K., et al. J. Allergy Clin. Immunol. 125(6):1395-1399(2010)
Tomsig, J.L., et al. J. Biol. Chem. 278(12):10048-10054(2003)

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$ 295.00
$ 99.00
Cat# AP13480b
(40 western blots)
Availability: In Stock
Bulk Size
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