RNASE6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q93091 |
Other Accession | NP_005606.1 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 17196 Da |
Antigen Region | 119-147 aa |
Gene ID | 6039 |
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Other Names | Ribonuclease K6, RNase K6, 3127-, RNASE6, RNS6 |
Target/Specificity | This RNASE6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-147 amino acids from the C-terminal region of human RNASE6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RNASE6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RNASE6 |
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Synonyms | RNS6 |
Function | Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146). Has potent antibacterial activity against a range of Gram-positive and Gram- negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320). |
Cellular Location | Secreted. Lysosome. Cytoplasmic granule |
Tissue Location | Highly expressed in spleen (at protein level) (PubMed:8836175, PubMed:25075772). Has little or no expression in healthy kidneys (at protein level) (PubMed:25075772). Detected in interstitial leukocytes in infected kidneys (at protein level) (PubMed:25075772). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level) (PubMed:25075772). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle (PubMed:8836175, PubMed:25075772). Also expressed in monocytes and neutrophils (PubMed:8836175). |
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Provided below are standard protocols that you may find useful for product applications.
Background
RNASE6 may have a role in host defense.
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Cho, S., et al. Genomics 85(2):208-220(2005)
Deming, M.S., et al. Genome Res. 8(6):599-607(1998)
Rosenberg, H.F., et al. Nucleic Acids Res. 24(18):3507-3513(1996)
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