|Application ||WB, E|
|Calculated MW||75032 Da|
|Antigen Region||466-494 aa|
|Other Names||NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8, NLRP10, NALP10, NOD8, PYNOD|
|Target/Specificity||This NLRP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-494 amino acids from the C-terminal region of human NLRP10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NLRP10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP10, NOD8, PYNOD|
|Function||Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection|
|Tissue Location||Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level). Widely expressed with highest levels in heart, brain and skeletal muscle. Also expressed in liver, colon, dermis and epidermis. Little expression detected in myeloid cells or peripheral blood mononuclear cells.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq].
Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)
Imamura, R., et al. J. Immunol. 184(10):5874-5884(2010)
Ha, H.J., et al. Biochem. Genet. 47 (9-10), 665-670 (2009) :
Kinoshita, T., et al. J. Biol. Chem. 280(23):21720-21725(2005)
Wang, Y., et al. Int. Immunol. 16(6):777-786(2004)
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