|Application ||WB, E|
|Other Accession||Q63262, P31361, P56222, P31360, P20265, P79745, NP_006227.1|
|Predicted||Zebrafish, Mouse, Rat|
|Calculated MW||50327 Da|
|Antigen Region||294-323 aa|
|Other Names||POU domain, class 3, transcription factor 3, Brain-specific homeobox/POU domain protein 1, Brain-1, Brn-1, Octamer-binding protein 8, Oct-8, Octamer-binding transcription factor 8, OTF-8, POU3F3, BRN1, OTF8|
|Target/Specificity||This POU3F3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human POU3F3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POU3F3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
POU3F3 is a member of the class III POU family of transcription factors (see POU3F1; MIM 602479) that are expressed in the central nervous system. The POU domain in these proteins is required for high affinity binding to octamer DNA sequences (summarized by Sumiyama et al., 1996 [PubMed 8703082]).[supplied by OMIM].
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)
Kuhlbrodt, K., et al. J. Biol. Chem. 273(26):16050-16057(1998)
Sumiyama, K., et al. Mamm. Genome 9(2):180-181(1998)
Malik, K.F., et al. Brain Res. Mol. Brain Res. 45(1):99-107(1997)
Sumiyama, K., et al. J. Mol. Evol. 43(3):170-178(1996)
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