|Application ||WB, E|
|Other Accession||NP_001138481.1, NP_919423.1, NP_001138480.1, NP_008979.3|
|Calculated MW||57677 Da|
|Antigen Region||345-374 aa|
|Other Names||Butyrophilin subfamily 3 member A1, CD277, BTN3A1, BTF5|
|Target/Specificity||This BTN3A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-374 amino acids from the C-terminal region of human BTN3A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BTN3A1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.|
|Cellular Location||Cell membrane; Single- pass type I membrane protein|
|Tissue Location||Detected on T-cells, natural killer cells, dendritic cells and macrophages (at protein level). Ubiquitous Highly expressed in heart, pancreas and lung, Moderately expressed in placenta, liver and muscle.|
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Provided below are standard protocols that you may find useful for product applications.
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM].
Smith, I.A., et al. J. Immunol. 184(7):3514-3525(2010)
Shi, J., et al. Nature 460(7256):753-757(2009)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Rhodes, D.A., et al. Genomics 71(3):351-362(2001)
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