|Application ||WB, E|
|Other Accession||NP_001157588.1, NP_001157587.1, NP_001157586.1, NP_065089.2|
|Calculated MW||87144 Da|
|Antigen Region||610-639 aa|
|Other Names||Cas scaffolding protein family member 4, HEF-like protein, HEF1-EFS-p130Cas-like protein, HEPL, CASS4, C20orf32, HEFL|
|Target/Specificity||This CASS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 610-639 amino acids from the C-terminal region of human CASS4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CASS4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Docking protein that plays a role in tyrosine kinase- based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, focal adhesion|
|Tissue Location||Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Possible docking protein which may play a role for tyrosine-kinase-based signaling related to cell adhesion. Regulates FAK activity, focal adhesion integrity, and cell spreading.
Singh, M.K., et al. Mol. Biol. Cell 19(4):1627-1636(2008)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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