CASS4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9NQ75 |
Other Accession | NP_001157588.1, NP_001157587.1, NP_001157586.1, NP_065089.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 87144 Da |
Antigen Region | 610-639 aa |
Gene ID | 57091 |
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Other Names | Cas scaffolding protein family member 4, HEF-like protein, HEF1-EFS-p130Cas-like protein, HEPL, CASS4, C20orf32, HEFL |
Target/Specificity | This CASS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 610-639 amino acids from the C-terminal region of human CASS4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CASS4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CASS4 |
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Synonyms | C20orf32, HEFL |
Function | Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. |
Cellular Location | Cytoplasm, cytoskeleton. Cell junction, focal adhesion |
Tissue Location | Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines |
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Provided below are standard protocols that you may find useful for product applications.
Background
Possible docking protein which may play a role for tyrosine-kinase-based signaling related to cell adhesion. Regulates FAK activity, focal adhesion integrity, and cell spreading.
References
Singh, M.K., et al. Mol. Biol. Cell 19(4):1627-1636(2008)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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