|Application ||WB, E|
|Calculated MW||98768 Da|
|Antigen Region||168-197 aa|
|Other Names||NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5|
|Target/Specificity||This NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the N-terminal region of human NLRP6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NLRP6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity).|
|Cellular Location||Cytoplasm. Cell membrane. Nucleus membrane|
|Tissue Location||Highly expressed in granulocytes. Detected at much lower levels in T-cells|
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Provided below are standard protocols that you may find useful for product applications.
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).
Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Albrecht, M., et al. FEBS Lett. 538 (1-3), 173-177 (2003) :
Tschopp, J., et al. Nat. Rev. Mol. Cell Biol. 4(2):95-104(2003)
Grenier, J.M., et al. FEBS Lett. 530 (1-3), 73-78 (2002) :
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