|Application ||IHC-P, WB, E|
|Other Accession||Q5XIF6, P68368, P68367, P81948, NP_005991.1|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||49924 Da|
|Antigen Region||417-446 aa|
|Other Names||Tubulin alpha-4A chain, Alpha-tubulin 1, Testis-specific alpha-tubulin, Tubulin H2-alpha, Tubulin alpha-1 chain, TUBA4A, TUBA1|
|Target/Specificity||This TUBA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 417-446 amino acids from the C-terminal region of human TUBA4A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TUBA4A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
Houck, S.A., et al. PLoS ONE 5 (7), E11795 (2010) :
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
Fiore, G., et al. Neurosci. Lett. 394(1):57-62(2006)
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