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SYT6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q5T7P8 |
| Other Accession | NP_995320.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57325 Da |
| Antigen Region | 483-510 aa |
| Gene ID | 148281 |
|---|---|
| Other Names | Synaptotagmin-6, Synaptotagmin VI, SytVI, SYT6 |
| Target/Specificity | This SYT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-510 amino acids from the C-terminal region of human SYT6. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SYT6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYT6 |
|---|---|
| Function | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9R0N8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N8} [Isoform 2]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9R0N8}. Cell membrane {ECO:0000250|UniProtKB:Q9R0N8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R0N8} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.
References
Castillo Bennett, J., et al. J. Biol. Chem. 285(34):26269-26278(2010)
Dalgin, G.S., et al. J. Urol. 180(3):1126-1130(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Roggero, C.M., et al. Dev. Biol. 285(2):422-435(2005)
Craxton, M. Genomics 77 (1-2), 43-49 (2001) :
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