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SYT6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SYT6 Antibody (C-term) AP13548b
    SYT6 Antibody (C-term) (Cat. #AP13548b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SYT6 antibody detected the SYT6 protein (arrow).
  • IHC-P - SYT6 Antibody (C-term) AP13548b
    SYT6 Antibody (C-term) (Cat. #AP13548b)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SYT6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q5T7P8
Other Accession NP_995320.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57325 Da
Antigen Region 483-510 aa
Additional Information
Gene ID 148281
Other Names Synaptotagmin-6, Synaptotagmin VI, SytVI, SYT6
Target/Specificity This SYT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-510 amino acids from the C-terminal region of human SYT6.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYT6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYT6
Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity).
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9R0N8}; Single- pass membrane protein {ECO:0000250|UniProtKB:Q9R0N8} Isoform 2: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9R0N8}. Cell membrane {ECO:0000250|UniProtKB:Q9R0N8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9R0N8}
Research Areas
Citations (0)

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Background

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.

References

Castillo Bennett, J., et al. J. Biol. Chem. 285(34):26269-26278(2010)
Dalgin, G.S., et al. J. Urol. 180(3):1126-1130(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Roggero, C.M., et al. Dev. Biol. 285(2):422-435(2005)
Craxton, M. Genomics 77 (1-2), 43-49 (2001) :

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$ 295.00
$ 99.00
Cat# AP13548b
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(40 western blots)
Availability: In Stock
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