|Application ||WB, IF, E|
|Calculated MW||18385 Da|
|Antigen Region||124-151 aa|
|Other Names||Eosinophil cationic protein, ECP, 3127-, Ribonuclease 3, RNase 3, RNASE3, ECP, RNS3|
|Target/Specificity||This RNASE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-151 amino acids from the C-terminal region of human RNASE3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNASE3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.|
|Cellular Location||Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus|
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Provided below are standard protocols that you may find useful for product applications.
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity.
Peona, V., et al. J Asthma 47(2):131-134(2010)
Kang, I., et al. Eur Arch Otorhinolaryngol 267(3):391-395(2010)
Jonsson, U.B., et al. BMC Pulm Med 10, 36 (2010) :
Kato, M., et al. Int. Arch. Allergy Immunol. 152 SUPPL 1, 62-66 (2010) :
Chang, K.C., et al. BMC Cell Biol. 11, 6 (2010) :
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