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RNASE3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P12724 |
| Other Accession | NP_002926.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18385 Da |
| Antigen Region | 124-151 aa |
| Gene ID | 6037 |
|---|---|
| Other Names | Eosinophil cationic protein, ECP, 3127-, Ribonuclease 3, RNase 3, RNASE3, ECP, RNS3 |
| Target/Specificity | This RNASE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-151 amino acids of human RNASE3. |
| Dilution | IF~~1:10~50 WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNASE3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RNASE3 |
|---|---|
| Synonyms | ECP, RNS3 |
| Function | Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. |
| Cellular Location | Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity.
References
Peona, V., et al. J Asthma 47(2):131-134(2010)
Kang, I., et al. Eur Arch Otorhinolaryngol 267(3):391-395(2010)
Jonsson, U.B., et al. BMC Pulm Med 10, 36 (2010) :
Kato, M., et al. Int. Arch. Allergy Immunol. 152 SUPPL 1, 62-66 (2010) :
Chang, K.C., et al. BMC Cell Biol. 11, 6 (2010) :
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