|Application ||WB, E|
|Other Accession||Q91ZQ0, Q99KU0, NP_112200.2|
|Calculated MW||46238 Da|
|Antigen Region||377-406 aa|
|Other Names||Vacuole membrane protein 1, Transmembrane protein 49, VMP1, TDC1, TMEM49|
|Target/Specificity||This TMEM49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-406 amino acids from the C-terminal region of human TMEM49.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMEM49 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions.|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Vacuole membrane; Multi-pass membrane protein Endoplasmic reticulum|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity).
Pardo, R., et al. Pancreatology 10(1):19-26(2010)
Calvo-Garrido, J., et al. Mol. Biol. Cell 19(8):3442-3453(2008)
Fujita, S., et al. J. Mol. Biol. 378(3):492-504(2008)
Sauermann, M., et al. Oncogene 27(9):1320-1326(2008)
Ropolo, A., et al. J. Biol. Chem. 282(51):37124-37133(2007)
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