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SGMS1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SGMS1 Antibody (N-term) AP13562a
    SGMS1 Antibody (N-term) (Cat. #AP13562a) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SGMS1 antibody detected the SGMS1 protein (arrow).
  • IHC-P - SGMS1 Antibody (N-term) AP13562a
    SGMS1 Antibody (N-term) (Cat. #AP13562a)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SGMS1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86VZ5
Other Accession Q8VCQ6, NP_671512.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49208 Da
Antigen Region 24-53 aa
Additional Information
Gene ID 259230
Other Names Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1, MOB, SMS1, TMEM23
Target/Specificity This SGMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human SGMS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSGMS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SGMS1
Synonyms MOB, SMS1, TMEM23
Function Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Brain, heart, kidney, liver, muscle and stomach.
Research Areas
Citations (0)

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The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lafont, E., et al. Cell Death Differ. 17(4):642-654(2010)
Vacaru, A.M., et al. J. Cell Biol. 185(6):1013-1027(2009)
Wang, W., et al. Plant Cell 20(11):3163-3179(2008)
Jin, Z.X., et al. Int. Immunol. 20(11):1427-1437(2008)

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$ 295.00
$ 99.00
Cat# AP13562a
(40 western blots)
Availability: In Stock
Bulk Size
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