|Application ||WB, IHC-P, E|
|Other Accession||Q8VCQ6, NP_671512.1|
|Calculated MW||49208 Da|
|Antigen Region||24-53 aa|
|Other Names||Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1, MOB, SMS1, TMEM23|
|Target/Specificity||This SGMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human SGMS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SGMS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MOB, SMS1, TMEM23|
|Function||Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Brain, heart, kidney, liver, muscle and stomach.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lafont, E., et al. Cell Death Differ. 17(4):642-654(2010)
Vacaru, A.M., et al. J. Cell Biol. 185(6):1013-1027(2009)
Wang, W., et al. Plant Cell 20(11):3163-3179(2008)
Jin, Z.X., et al. Int. Immunol. 20(11):1427-1437(2008)
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