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DOK7 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DOK7 Antibody (N-term) AP13568a
    DOK7 Antibody (N-term) (Cat. #AP13568a) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the DOK7 antibody detected the DOK7 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q18PE1
Other Accession NP_001158145.1, NP_775931.3
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53097 Da
Antigen Region 26-55 aa
Additional Information
Gene ID 285489
Other Names Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25
Target/Specificity This DOK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human DOK7.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDOK7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOK7
Synonyms C4orf25
Function Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Cellular Location Cell membrane; Peripheral membrane protein. Cell junction, synapse. Note=Accumulates at neuromuscular junctions
Tissue Location Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level)
Research Areas
Citations (0)

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The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.


Bergamin, E., et al. Mol. Cell 39(1):100-109(2010)
Srour, M., et al. Neuromuscul. Disord. 20(7):453-457(2010)
Maselli, R.A., et al. Hum. Mol. Genet. 19(12):2370-2379(2010)
Ben Ammar, A., et al. J. Neurol. 257(5):754-766(2010)
Vogt, J., et al. J. Med. Genet. 46(5):338-340(2009)

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$ 295.00
$ 99.00
Cat# AP13568a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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