|Application ||WB, E|
|Calculated MW||140130 Da|
|Antigen Region||63-91 aa|
|Other Names||Ubiquitin carboxyl-terminal hydrolase 40, Deubiquitinating enzyme 40, Ubiquitin thioesterase 40, Ubiquitin-specific-processing protease 40, USP40|
|Target/Specificity||This USP40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-91 amino acids from the N-terminal region of human USP40.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||USP40 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be catalytically inactive.|
|Tissue Location||Broadly expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
Wu, Y.R., et al. Clin. Chim. Acta 411 (13-14), 955-958 (2010) :
Li, Y., et al. Hum. Mutat. 27(10):1017-1023(2006)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)
Puente, X.S., et al. Nat. Rev. Genet. 4(7):544-558(2003)
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